Studies on the Pathophysiology of
نویسندگان
چکیده
Posttransfusion purpura typically occurs in PL negative blood recipients who have been previously immunized to the PL antigen. Following transfusion. severe thrombocytopenia develops with the formation of anti-PL . Since the patients’ platelets lack the PL antigen. one would not expect this antibody to destroy autologous platelets. In this study we show that PL antigen exists in stored blood and can absorb to PL negative platelets making them PL reactive. Incubating PL ( ) platelets with ultracentrifuged plasma from PLAI ( + ) blood donors allowed anti PLAl to bind to PL ( ) platelets. Control plasma from PLA1 ( blood donors did not lead to anti-PL binding. Using an inhibition assay, we showed that stored blood contains PL material that was not removed by ultracentrifugation.
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